Product | Pythia Biotech Co., Ltd.

Explore our innovative
Organ-on-Chip technology

Organ-on-Chip technology represents a cutting-edge in vitro testing system for drug development, effectively simulating the functions of human organs. By providing more accurate test results, this innovative approach accelerates the drug development process while significantly reducing experimental costs. It paves the way for safer and more efficient therapeutic solutions.

Traditional
cell culture

✘ Simulated physiology

✘ Intercellular interactions

✔ Gene differences regulation

Traditional

animal testing

✔ Simulated physiology

✔ Intercellular interactions

✘ Gene differences regulation

Organ-on-Chip

✔ Simulated physiology

✔ Intercellular interactions

✔ Gene differences regulation

CORE TECHNOLOGY

Technical Highlights

Organ-on-Chip technology integrates multiple disciplines, including microfluidics, microfabrication, biomaterials engineering, and biology, to create a sophisticated microphysiological environment. This innovative system offers a testing platform that closely mimics real human physiological conditions.

Traditional 2D or 3D cell cultures often lack key physiological functions such as membrane contractions, lung alveolar movements, muscle contractions, circulation simulation, and essential intercellular interactions. Additionally, animal testing can introduce variability due to genetic differences.

By replacing conventional cell cultures and animal testing, Organ-on-Chip technology opens up new avenues for biomedical research, drug development, and personalized medicine, providing more accurate and relevant results for advancing healthcare solutions.

Tumor Microenvironment (TME) Chip

The TME-chip is an advanced bio-chip designed to create a dynamic tumor microenvironment. The TME-chip faithfully recreates a pathological environment in 3D space, effectively mimicking the structure and composition of a cold tumor in vitro. It is particularly valuable for drug and toxin testing, with its current clinical applications focusing on drug testing for non-small cell lung cancer, especially in relation to combined therapies involving chemotherapy and immunotherapy.

Liver Chip

The Liver-chip is an innovative PDMS-based bio-chip designed for liver tissue engineering. Utilizing dielectrophoresis (DEP) forces, hepatocytes and non-parenchymal cells are directed into 3D chambers within the chip, where they are patterned and cultured in a 3D microenvironment.

This advanced biotechnological product integrates cutting-edge Micro-Electro-Mechanical Systems (MEMS) technology with cell culture techniques to recreate liver tissue in vitro mimicking the physiological conditions. By closely mimicking the functionality of normal liver tissue—such as the secretion of albumin and urea, along with the activity of AST/ALT and CYP enzymes—this technology serves as a valuable platform for drug toxicity testing.

Compared to traditional cell culture methods, the Liver-chip provides a more accurate representation of liver tissue, making it an essential tool for preclinical toxicity studies and enhancing our understanding of liver function and drug interactions.